Yes, not on a D450 but on later Lowreys and many other digital instruments. Causes have included faulty ribbon cables, unseated cables and ICs and, in one case, a ribbon cable with a board mounting screw driven through it - a Lowrey NT400 Heritage. Occasional hangs and lock-ups with no apparent cause on digital instruments from Yamaha, Kawai and Technics (and probably others). Usual computer remedy "Turn it off and back on again!"
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